Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

T cell activation involves specific interactions between the TCR and peptides presented by the MHC. This engagement leads to phosphorylation and subsequent internalization of the TCR complex. By analyzing the kinetics of the internalization of TCR, we found that the rate of TCR down-regulation was proportional to the square of the TCR density. Mathematical modeling of TCR interactions indicates that such a relation is only possible if TCR dimerize before internalization. By mathematical analysis, our data would also be compatible with trimer but not larger oligomer formation. Thus, minimal TCR oligomerization is an essential step for peptide-mediated T cell activation.

Original publication

DOI

10.1002/(SICI)1521-4141(199808)28:08<2571::AID-IMMU2571>3.0.CO;2-T

Type

Journal article

Journal

Eur J Immunol

Publication Date

08/1998

Volume

28

Pages

2571 - 2579

Keywords

Animals, Antigen Presentation, Dimerization, Down-Regulation, In Vitro Techniques, Kinetics, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Mice, Mice, Transgenic, Models, Biological, Protein Conformation, Receptors, Antigen, T-Cell, T-Lymphocytes, Viral Proteins