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Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.

Type

Journal article

Journal

J Virol

Publication Date

08/1997

Volume

71

Pages

5764 - 5768

Keywords

Animals, Antibodies, Monoclonal, Lymphocytic choriomeningitis virus, Mice, Mice, Inbred C57BL, Mutation, T-Lymphocytes, Cytotoxic