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CD45 is expressed on all B cells and has been reported to be essential for their B cell receptor mediated stimulation. The present study addressed T-cell-independent B cell responses in CD45-deficient mice using the glycoprotein (G) of vesicular stomatitis virus (VSV) as a model antigen. VSV-G exists in two forms exhibiting different degrees of repetitiveness. In mice, the two forms of VSV-G induce either a type 1 or a type 2 T-cell-independent B cell response. We found that CD45-deficient mice mounted T-cell-independent B cell responses to both forms of VSV-G. This demonstrates that the B cell receptor complex is able to generate a functional signal in the absence of CD45, provided the cross-linking stimulus is sufficiently strong.

Original publication




Journal article


Cell Immunol

Publication Date





12 - 15


Animals, Antibodies, Viral, Antigens, Viral, B-Lymphocytes, Cross-Linking Reagents, Gene Targeting, Glycoproteins, Immunoglobulin M, In Vitro Techniques, Leukocyte Common Antigens, Lymphocyte Activation, Membrane Glycoproteins, Mice, Mice, Mutant Strains, Neutralization Tests, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Receptors, Antigen, B-Cell, T-Lymphocytes, Helper-Inducer, Vesicular stomatitis Indiana virus, Viral Envelope Proteins