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The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and by T cells. In both humans and mice, KLRG1 identifies Ag-experienced T cells that are impaired in their proliferative capacity but are capable of performing effector functions. In this study, we identified E-cadherin as a ligand for murine KLRG1 by using fluorescently labeled, soluble tetrameric complexes of the extracellular domain of the murine KLRG1 molecule as staining reagents in expression cloning. Ectopic expression of E-cadherin in B16.BL6 target cells did not affect cell-mediated lysis by lymphokine-activated NK cells and by CD8 T cells but inhibited Ag-induced proliferation and induction of cytolytic activity of CD8 T cells. E-cadherin is expressed by normal epithelial cells, Langerhans cells, and keratinocytes and is usually down-regulated on metastatic cancer cells. KLRG1 ligation by E-cadherin in healthy tissue may thus exert an inhibitory effect on primed T cells.

Original publication

DOI

10.4049/jimmunol.176.3.1311

Type

Journal article

Journal

J Immunol

Publication Date

01/02/2006

Volume

176

Pages

1311 - 1315

Keywords

Animals, Antigens, CD8-Positive T-Lymphocytes, Cadherins, Cell Division, Cell Line, Growth Inhibitors, Killer Cells, Lymphokine-Activated, Ligands, Melanoma, Experimental, Mice, Mice, Inbred C57BL, Mice, Transgenic, Receptors, Immunologic