Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

T cell activation by APCs is positively and negatively regulated by members of the B7 family. We have identified a previously unknown function for B7 family-related protein V-set and Ig domain-containing 4 (VSIG4). In vitro experiments using VSIG4-Ig fusion molecules showed that VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production. Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th cell-dependent IgG responses. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.

Original publication




Journal article


J Clin Invest

Publication Date





2817 - 2826


Amino Acid Sequence, Animals, Autoimmune Diseases, B7-1 Antigen, B7-H1 Antigen, Cell Line, Cell Proliferation, Female, Gene Expression, Humans, Immunoglobulins, Interferon-gamma, Interleukin-2, Lipopolysaccharides, Liver, Lymphocyte Activation, Macrophages, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, Myocarditis, Peptides, Programmed Cell Death 1 Ligand 2 Protein, Receptors, Complement, Sequence Homology, Amino Acid, T-Lymphocytes, Thioglycolates