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Mice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N-region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wild-type controls. We find surprisingly normal immune responses in TdT0 mice, as regards both efficiency and specificity. This provokes a reconsideration of the assumption that N-region diversity is required for an effective T and B cell repertoire.

Original publication




Journal article


Eur J Immunol

Publication Date





3115 - 3122


Amino Acid Sequence, Animals, Base Sequence, DNA Nucleotidylexotransferase, Epitopes, Immunoglobulins, Lymphocytic choriomeningitis virus, Mice, Mice, Mutant Strains, Molecular Sequence Data, Neutralization Tests, Polymorphism, Genetic, Receptors, Antigen, T-Cell, Vesicular stomatitis Indiana virus