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PURPOSE OF REVIEW: In a seminal paper in 2006, Yamanaka and coworkers reported the reprogramming of terminally differentiated murine cells to a pluripotent state, largely indistinguishable from conventional embryonic stem cells. The introduction of defined transcription factors via retroviral transduction revealed, in principle, how pluripotency, once thought to be lost at an early stage of embryogenesis, could be reawakened in adulthood. RECENT FINDINGS: Since these initial findings, induced pluripotency has been reported using human as well as mouse cells and through the introduction of recombinant proteins, thereby avoiding the use of retroviruses for genetic modification. This approach, therefore, harnesses the traditional plasticity of embryonic stem cells as a source of therapeutic cell types and tissues, but without the many ethical issues with which they have become synonymous. The potential for exploiting pluripotency in this way also raises the tantalizing prospect of personalized therapies, spawning a new chapter in the story of regenerative medicine. SUMMARY: Given the promise of induced pluripotency and the disarming ease with which it can be achieved, it is perhaps timely to address the likely effect it will have on the field of transplantation and to ask whether the generation of induced pluripotent stem cells of autologous origin is ever likely to render redundant the need for transplantation tolerance.

Original publication

DOI

10.1097/MOT.0b013e32832e9424

Type

Journal article

Journal

Curr Opin Organ Transplant

Publication Date

08/2009

Volume

14

Pages

321 - 325

Keywords

Animals, Cell Differentiation, Cell Lineage, Cell Survival, Embryonic Stem Cells, Gene Expression Regulation, Developmental, Genetic Therapy, Humans, Mice, Pluripotent Stem Cells, Regenerative Medicine, Stem Cell Transplantation, Transplantation Tolerance, Transplantation, Autologous