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Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

Original publication




Journal article


J Infect Dis

Publication Date





1352 - 1355


K13-propeller, artemisinin resistance, sub-Saharan Africa, Alleles, Antimalarials, Artemisinins, Asia, Southeastern, Drug Resistance, Gene Frequency, Humans, Malaria, Falciparum, Mutation, Plasmodium falciparum, Polymorphism, Single Nucleotide