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Phosphoinositide signalling regulates a series of important neuronal processes that are thought to be altered in mood disorders. Furthermore, mood-stabilizing drugs inhibit key enzymes that regulate phosphoinositide production and alter neuronal growth cone morphology in an inositol-reversible manner. Inositol is taken up by neurons from the extracellular fluid, presumably via membrane transporters; it can also be synthesized by the enzyme MIP-synthase (myo-inositol-1-phosphate synthase) and, in addition, it is generated by inositol phospholipid hydrolysis. The neuronal-specific HMIT (H(+)-myo-inositol transporter) represents a potential regulator of inositol signalling in neurons that warrants further investigation.

Original publication

DOI

10.1042/BST0371139

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

10/2009

Volume

37

Pages

1139 - 1143

Keywords

Animals, Antimanic Agents, Brain, Carbamazepine, Glucose Transport Proteins, Facilitative, Humans, Inositol, Lithium Compounds, Membrane Transport Proteins, Neurons, Phosphatidylinositols, Signal Transduction, Valproic Acid