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In the past year, the major advances in understanding the genetics of autoimmune disease in both man and mouse have been made as a result of using the positional cloning approach. Construction of congenic mouse strains, and, in humans, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.


Journal article


Curr Opin Immunol

Publication Date





786 - 792


Animals, Autoimmune Diseases, Chromosome Mapping, Diabetes Mellitus, Type 1, Disease Models, Animal, Genes, MHC Class II, Genetic Linkage, Humans, Mice, Receptors, Immunologic, Repetitive Sequences, Nucleic Acid