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Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial state.

Original publication

DOI

10.1016/j.immuni.2017.03.005

Type

Journal article

Journal

Immunity

Publication Date

03/2017

Volume

46

Pages

337 - 339

Addresses

Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

Keywords

Animals, Mice, Membrane Proteins, Signal Transduction