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Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system.

Original publication

DOI

10.3390/vaccines6030037

Type

Journal article

Journal

Vaccines

Publication Date

02/07/2018

Volume

6

Addresses

Jenner Institute, University of Oxford, Oxford OX3 7BN, UK. mmohsen@qf.org.qa.