Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Leprosy is a chronic disease caused by infection with Mycobacterium leprae, which is manifested across a wide clinical spectrum. There is evidence that susceptibility both to leprosy per se and to the clinical type of leprosy is influenced by host genetic factors. This paper describes the application of an identity by descent regression search for genetic determinants of leprosy type among families from Karonga District, Northern Malawi. Suggestive evidence was found for linkage to leprosy type on chr 21q22 (P<0.001). The methodological implications of the approach and the findings are discussed.

Original publication

DOI

10.1038/sj.gene.6364062

Type

Journal article

Journal

Genes Immun

Publication Date

05/2004

Volume

5

Pages

221 - 225

Keywords

Chromosomes, Human, Pair 21, Female, Genetic Linkage, Genetic Predisposition to Disease, Humans, Leprosy, Malawi, Male, Pedigree, Regression Analysis