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Few advances have been so widely acclaimed in biology as the seminal demonstration that adult somatic cells can be induced to acquire the phenotype and differentiation potential of embryonic stem cells. The capacity to produce patient-specific stem cells that are truly pluripotent has raised prospects for the treatment of many degenerative diseases through replacement of the affected cell types. In the race to the clinic, however, questions surrounding the potential immunogenicity of such cells have been largely overlooked. Here, I explore the extent of the challenges ahead and suggest that the induction of tolerance to such cells will be crucial to the future success of induced pluripotency.

Original publication

DOI

10.1038/nri2878

Type

Journal article

Journal

Nat Rev Immunol

Publication Date

12/2010

Volume

10

Pages

868 - 875

Keywords

Adult, Animals, Cell Transplantation, Embryonic Stem Cells, Humans, Induced Pluripotent Stem Cells, Mice, Rats, Transcription Factors, Transduction, Genetic, Transplantation Tolerance