Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
Schmidt F., Thywißen A., Goldmann M., Cunha C., Cseresnyés Z., Schmidt H., Rafiq M., Galiani S., Gräler MH., Chamilos G., Lacerda JF., Campos A., Eggeling C., Figge MT., Heinekamp T., Filler SG., Carvalho A., Brakhage AA.
Schmidt el al. show that lipid rafts in phagolysosomal membranes of macrophages depend on flotillins. Lipid rafts are required for assembly of vATPase and NADPH oxidase. Conidia of the human-pathogenic fungus Aspergillus fumigatus dysregulate assembly of flotillin-dependent lipid rafts in the phagolysosomal membrane and can thereby escape phagolysosomal digestion.