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News

Oxford University buildings

BSI Oxford Immunology Symposium 2025

T cells (red) targeting a cancer cell (green)

New episode of To Immunity and Beyond: Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes

Reversing resistance to cancer immune therapy with antibodies

A new study led by Professor Ignacio Melero of NDM's Centre for Immuno-oncology and the University of Navarra and has highlighted a way to combat resistance to cancer immunotherapy in solid tumours by using antibodies that target GDF-15 protein.

Researchers provide a perspective on mapping the bone marrow using new spatial transcriptomic technologies

RDM researchers have outlined the potential benefits and limitations of new spatial transcriptomic technologies for mapping the bone marrow in patients with blood cancer.

Trial results for first vaccine against blood-stage malaria show it is well-tolerated and offers effective protection

Results of a clinical trial into a new malaria vaccine candidate (RH5.1/Matrix-M) show it is well-tolerated and offers effective protection against the blood-stage of the disease – the first inoculation to do so.

Woman using asthma inhaler

First new treatment for asthma attacks in 50 years

An injection given during some asthma and chronic obstructive pulmonary disease (COPD) attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30 percent.

Woman sneezing into a tissue

Reconstructing a lifetime of flu infections to understand long-term trends

Using antibody data and mathematical modelling, a new study from researchers at the Pandemic Sciences Institute estimates annual patterns of influenza infection and protection over the past fifty years.

Launch of 'To Immunity and Beyond' podcast series

Scientist with face mask and goggles

Study maps out next generation of drug targets in autoimmune diseases

In a world first, researchers at the Kennedy Institute of Rheumatology and the Nuffield Department of Medicine have mapped the cellular dynamics following treatment with the most commonly used advanced therapy in autoimmune diseases. They have discovered why some patients benefit from this therapy while others do not, potentially paving the way for new therapies.

Scientist reaching for a vial in a vaccine production line.

Professor Ahmed Awarded Funding To Create World’s First Ovarian Cancer Prevention Vaccine

Researchers at the MRC WIMM have been awarded up to £600,000 from Cancer Research UK (CRUK) to create the world’s first vaccine to prevent ovarian cancer.

Vietnamese woman holding a sign

New point-of-care testing to improve antibiotic use in Vietnam

High levels of acceptability for a point-of-care testing service to improve antibiotic distribution for in Vietnamese pharmacies have been discovered by the Oxford University Clinical Research Unit (OUCRU), part of the Nuffield Department of Medicine.

Woman using asthma inhaler

Improving understanding of lung microbiome in severe asthma patients

Researchers in the Nuffield Department of Medicine, supported by NIHR Oxford Biomedical Research Centre (BRC), have discovered a link between potentially pathogenic bacteria and airways inflammation in people with severe asthma.

Developing the first cancer prevention vaccine for Lynch syndrome

Scientists from the Centre for Human Genetics at Nuffield Department of Medicine are taking the initial steps in developing the UK’s first vaccine to prevent cancer in people with Lynch syndrome, thanks to funding from Cancer Research UK.

Adoptive T cell therapy shows an enhanced tumour response

The Van den Eynde groups at the Ludwig Institute for Cancer Research in Brussels and Oxford have demonstrated that deletion of PHD2/3 enzymes in CD8 T cells shows an enhanced tumour response in various cancer models.

Preventive vaccination could be a key strategy against Lassa fever

Researchers at the University of Oxford and the University of Liverpool have for the first time been able to estimate the current burden of Lassa fever, project the impacts of a Lassa fever vaccination programme, and demonstrate how it may help avoid the next pandemic.

A blood test done by the study team as part of routine monitoring of study participants in Papua, Indonesia.

OUCRU and Universitas Indonesia complete historic malaria vaccine trial

The Faculty of Medicine Universitas Indonesia (FMUI) and OUCRU Indonesia have completed a phase 2 clinical trial for two new malaria vaccines developed by Sanaria Inc. This is the first malaria vaccine trial ever conducted in Indonesia and the first in the Asia-Pacific region in over 30 years.

Structure of a key “trigger” of the immune response solved

New research identifies autoimmunity against a key anti-inflammatory regulator

A ground-breaking study, published by the New England Journal of Medicine, has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function.

Coughing woman

ORTU awarded £2.8m to study treatment for pleural infection

The Oxford Respiratory Trials Unit (ORTU) at the Nuffield Department of Medicine has been awarded a £2.8 million grant from the National Institute for Health and Care Research Health Technology Assessment (NIHR HTA) to conduct the MIST4 study.

A malaria febrile child diagnosed and treated in early morning Nov 2023 in Mtwara, Tanzania

Policy changes needed as drug-resistant malaria spreads in East Africa

The efficacy of artemisinin derivatives, the cornerstone of current treatments for malaria, is being compromised in Africa where over 1,000 children are estimated to die each day from the disease. The spread of artemisinin-resistant malaria parasites across East Africa and beyond could result in millions more deaths without immediate health policy changes, warn experts in a paper published in Science.

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