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News

Scientists in the Department of Paediatrics discover antibody combinations that block over 90% of malaria parasite growth

In an important discovery for the next-generation of malaria vaccines, University of Oxford researchers in the Department of Paediatrics, in collaboration with the Scripps Institute, have identified how antibodies can be over 90% effective at preventing malaria parasites from growing in certain combinations.

Interleukin 10 (IL-10) cytokine protein - looks like a red ribbon

Decades old puzzle solved as scientists uncover cause of inflammatory bowel disease

Scientists have identified the missing link between a long-known genetic signal in inflammatory bowel disease and a damaging immune response that switches off the body’s natural control of inflammation - opening the door to faster diagnosis and targeted treatment.

A cancer cell is being targeted by immune T cells

Researchers uncover hidden mechanism behind a major cancer therapy target

Kennedy researchers have revealed how one of the immune system's most important regulatory pathways operates at the earliest moments of T cell activation, providing new insights that could help improve cancer immunotherapy.

Workshop post-it stickers on what does immunology tolerance mean to you

Sounds of Tolerance

What does tolerance sound like? A new public engagement project, Sounds of Tolerance, is bringing together scientists, musicians and people living with Inflammatory Bowel Disease to explore the science and lived experience of tolerance through music.

Professor Teresa Lambe

Oxford Bundibugyo ebolavirus vaccine candidate receives CEPI backing

The Coalition for Epidemic Preparedness Innovations (CEPI) has announced today that it will urgently accelerate the development of three investigational vaccines targeting the Bundibugyo ebolavirus that has caused a rapidly spreading epidemic in the Democratic Republic of the Congo (DRC) and neighbouring Uganda, including one being developed by the Oxford Vaccine Group at the University of Oxford.

Irina Udalova

Major MRC funding for Irina Udalova to unravel neutrophil behaviour across immune pathologies

Prof Irina Udalova has received a programme grant of £2.7M from the Medical Research Council (MRC) to investigate how neutrophils – a type of white blood cell that forms the body’s first line of defence – adapt their behaviour to tissue requirements and contribute to immune diseases, leading to the development of a new class of neutrophil-targeted therapeutics.

Creative image of embryonic stem cells

Study reveals blood stem cells can ‘remember’ inflammation

Researchers have discovered that some human blood stem cells retain a lasting “memory” of inflammation, a finding that could help explain links between ageing, chronic disease, and blood cancers

Ebola virus

Statement on vaccine efforts relating to the Bundibugyo Ebolavirus outbreak in the Democratic Republic of the Congo

In response to the current Bundibugyo Ebolavirus outbreak in the Democratic Republic of the Congo, the Oxford Vaccine Group (OVG) is working urgently with Oxford’s own Clinical BioManufacturing Facility and the Serum Institute of India Pvt. Ltd. (SIIPL), to rapidly produce and scale doses of our ChAdOx-based monovalent Bundibugyo Ebolavirus candidate vaccine, ChAdOx1 BDBV.

Researcher hanlding patient samples in a lab.

Reversing T cell exhaustion improves effectiveness of myeloma immunotherapies

Researchers at the Icahn School of Medicine at Mount Sinai, Bristol Myers Squibb (BMS), and the University of Oxford have discovered a way to give worn-out immune cells a second wind in the fight against multiple myeloma.

Research uncovers new mechanism controlling inflammation in immune cells

Researchers from the University of Oxford's Radcliffe Department of Medicine and the University of Surrey have discovered that a key immune enzyme controls inflammation in a way that does not depend on its well-known function.

Podcast. The MRC Centre of Research Excellence in Exposome Immunology

A conversation with Professor Sheena Cruickshank about the new MRC Centre of Research Excellence in Exposome Immunology.

Researchers find clue to how Sjögren’s disease persists

A new study has found that a protein TRIM21 linked to Sjögren’s disease may be fuelling the condition in an unexpected way. Researchers at the Kennedy Institute of Rheumatology have discovered that during a specific type of cell death, TRIM21 is released and combines with antibodies to overstimulate the immune system, potentially maintaining the symptoms of Sjögren’s disease.

Liver organoid visualised by live multi-colour fluorescence confocal imaging

Oxford-ZEISS Centre of Excellence in Biomedical Imaging to develop next-generation imaging technology for drug-profiling in live cells

The pioneering technology will be able to precisely quantify drug behaviour at the cellular level for the development of novel therapeutics.

Oxford-led study reveals new way to activate protein kinases, opening new therapeutic possibilities

Researchers at the University of Oxford have developed a new strategy to activate protein kinases — a major class of enzymes that regulate essential cellular processes — offering a potential pathway to treat diseases where current therapies remain limited.

An image of a glowing anatomical heart

Study identifies immune–metabolic pathway as potential target in diabetic heart disease

Researchers have shown that a drug originally developed to lower blood sugar can improve heart function and reduce inflammation in a preclinical model of type 2 diabetes.

Professor James Fullerton and Dr Loren Kell

New industrial partnership to advance human immunology research and accelerate therapeutic development

A new collaboration between the Translational Pharmacology Group at NDORMS and global biopharmaceutical company UCB aims to promote understanding of human adaptive immunity and catalyse the development of new treatments for patients with immune-mediated conditions.

New research reveals why some oesophageal cancers are so hard to treat

Research published today in Science Advances has uncovered new insights into why the most aggressive oesophageal cancers are so difficult to treat and how the body’s own defence systems are helping them to thrive.

3D illustration of human immune cells - mast cell, basophil, eosinophil - involved in allergic reactions and inflammation.

New study reveals how blood cell production responds to parasite infection

Research led by the Nerlov Group in the MRC Molecular Haematology Unit provides the first detailed explanation of how parasite-fighting immune cells are selectively increased following infection.

Cytotoxic T cell

Anchoring a key immune molecule boosts T cell responses

Researchers at the Kennedy Institute of Rheumatology have found that physically resisting the formation of an immunological synapse actually promotes a stronger immune response. The findings could help explain how immune responses become weakened in cancer and chronic infection and inform the design of more effective vaccines.

Paresh Vyas receives CRUK Discovery Programme Award

Congratulations to Professor Paresh Vyas, who has been awarded a Discovery Research grant from Cancer Research UK to investigate cancer immunotherapies.

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