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Our Team
- Alison Simmons
- Simon Travis
- Oliver Bannard
- Lynn Dustin
- Ellie Barnes
- John Frater
- Chris Willberg
- Benoit van den Eynde
- Philip Maini
- Helen Byrne
- Peter Minary
- Oliver Pybus
- Angela McLean
- Juha Huiskonen
- Oreste Acuto
- Elena Di Daniel
- Sir Marc Feldmann FRS
- Astrid Iversen
- Tim Maughan
- Fiona McCann
- Mark Middleton
- Smita Patel
- John Todd
- Patrick Waters
- Georgina Kerr
- Tanmay Bharat
- Fiona Powrie FRS
- Vincenzo Cerundolo
- Jelena Bezbradica Mirkovic
- Luke Jostins
- Anna Katharina (Katja) A Simon
- Alison Banham
- Andrew Pollard
- Angela Vincent
- Audrey Gérard
- Daniel C Anthony
- Francis Szele
- Gabriele DeLuca
- Georg Holländer
- Gil McVean
- Graham Ogg
- Hal Drakesmith
- Ingrid Granne
- Jan Rehwinkel
- Joanna Hester
- Kathryn Wood
- Kim Midwood
- Lars Fugger
- Mark Coles
- Michael Dustin
- Paul Bowness
- Philip Goulder
- Sarosh Irani
- Adrian Hill
- Andrew McMichael
- Anton van der Merwe
- Chris O'Callaghan
- Christoph Tang
- David Greaves
- E Yvonne Jones
- Eva Gluenz
- Geraldine Gillespie
- Helen McShane
- Holm Uhlig
- Julian Knight
- Len Seymour
- Marion Brown
- Nicole Zitzmann
- Omer Dushek
- Paul Fairchild
- Paul Klenerman
- Persephone Borrow
- Peter Ratcliffe
- Petros Ligoxygakis
- Quentin Sattentau
- Richard Cornall
- Sarah Rowland Jones
- Susanna Dunachie
- William James
- Xin Lu
- Carolina Arancibia
- Jon Austyn
- Sally Cowley
- Calliope Dendrou
- Dominic Kwiatkowski
- Kay Grunewald
- Thomas Bowden
- Sergi Padilla-Parra
- Peijun Zhang
- Robert Gilbert
- Christophe Fraser
- Peter Gething
- Angela Brueggemann
- Peter Simmonds
- Luzheng Xue
- Ervin Fodor
- Keith Gull
- Susan Lea
- Kevin Maloy
- Herman Waldmann
- Nicola Sibson
- Martin Maiden
- Pat Nuttall
- Bungo Akiyoshi
- Matt Higgins
- John Vakonakis
- Jonathan Hodgkin
- Mark Howarth
- Adrian Smith
- Lucy Dorrell
- Tomas Hanke
- Arturo Reyes-Sandoval
- Martin Bachmann
- Irina Redchenko
- Tao Dong
- Aris Katzourakis
- Kayla King
- Katrina Lythgoe
- Nicola Ternette
- Philippa Matthews
- Derrick Crook
- Satish Keshav
- Tim Peto
- Daniel Wilson
- David Wyllie
- Ling-Pei Ho
- Mads Gyrd-Hansen
- Sarah Gilbert
- Simon Draper
- Irina Udalova
- Stephanie Dakin
- Paul Riley
- Angus Wann
- Tal Arnon
- Simon Davis
- Christian Eggeling
- Marco Fritzsche
- Thibault Griseri
- Nicole Horwood
- David Jackson
- Dominic Kelly
- Demin Li
- Claudia Monaco
- Udo Oppermann
- Frances Platt
- Stephen Sansom
- Jonathan Sherlock
- Sarah Snelling
- Alain Townsend
- Paresh Vyas
- Richard Williams
- Paul Wordsworth
- Gavin Screaton
- Alex Clarke
- Berlin-Oxford Initiative
- Dialling down inflammation in psoriasis
- Geometry is key to T-cell triggering
- Shieldin Complex
- Understanding how RIPK2 inhibitors affect ubiquitin-mediated inflammatory signalling
- Patterns of insecticide resistance affecting malaria control in Africa
- Could we work together with our bacteria to stop infection?
- Mechanistic models versus machine learning: a fight worth fighting for the biological community?
- New research makes progress towards general Salmonella vaccine
- Vaccinations and the fight against poverty
- Malaria’s ticking time bomb
- New evidence supports radical treatment of widespread form of malaria
- Development of a highly protective Zika vaccine through modulation of antigen membrane anchors
- Trial of ‘kick and kill’ approach to HIV cure leaves puzzles to be solved
- Controlling infection essential to tackle global anaemia
- Professor Molnár and team of international researchers demonstrate effects of the Zika virus
- MAIT cells protect against pulmonary Legionella longbeachae infection
- Tracking the evolution and transmission of yellow fever
- Using DNA sequencing and patient data to halt infection outbreak
- Award-winning citizen science project tackling TB gets millionth classification
- Regenerative medicine spinout OxStem launches subsidiaries
- Single cell analysis paves the way for better treatments for IBD
- UK-led study marks shift towards genetic era in tackling TB
- Addictive behaviours have strong links with ancient retroviral infection
- Pre-clinical success for universal flu vaccine offers hope
- Influenza virus molecules set immune response into overdrive
- Halting the spread of salmonella
- 'The Bacterial World' at the Oxford Natural History Museum
- Are there generic features of diseases such as Alzheimer's that can be explained from simple mechanistic models?
- Asia's invisible malaria, a photograph exhibition by Pearl Gan
- Parasites from medieval latrines unlock secrets of human history
- The Zika virus linked to microcephaly, discovered on the African continent
- Immune response explained by mathematics of narrow escapes
- Researchers find new cells that repair tissue
- SCIENCE BLOG: How can evolutionary biology help to get rid of antibiotic resistant bacteria?
- Naturally occurring compound spermidine boosts vaccine responses in old mice
- The global value of vaccination
- Rapidly spreading multidrug-resistant parasites render frontline malaria drug ineffective in southeast Asia
- New study shows faster way to cure vivax malaria
- Dissecting TNF signalling in inflammatory disease
- Researchers identify link in the treatment of inflammatory bowel disease (IBD)
- Flu antiviral has bigger benefits for sicker, older patients
- New therapeutic target identified in spondyloarthritis
- How HIV acquires its lipid membrane shell
- Removing body clock gene protects mice against pneumonia
- Typhoid vaccine over 81% effective in tackling disease in Nepal
- International neglect of typhoid outside rich countries threatens a new global health emergency
- Is mandatory vaccination the best way to tackle falling rates of childhood immunisation?
- Malnutrition linked with increased risk of Zika birth defects
- Leptin is the missing piece in the immunometabolism puzzle
- Modelling research aims to inform new WHO roadmap for neglected tropical diseases
- Determining the atomic structure of bacterial surface proteins in situ
- New MERS vaccine clinical trial starts in Saudi Arabia
- Oxford team to begin novel coronavirus vaccine research
- International research consortium activates clinical study for novel coronavirus in England and Scotland
- New target identified for repairing the heart after heart attack
- Meningococcal disease vaccines in the UK and Australia
- Outbreak: fighting coronavirus
-
COVID-19 Literature Reviews
- Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients
- Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis
- SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry
- Identification and characterization of an immunodominant SARS-CoV-2-specifc CD8 T cell response
- Gastrointestinal involvement attenuates COVID-19 severity and mortality
- Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome
- Coronavirus disease 2019 induced inflammatory response are associated with changes in lipid profiles
- Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity
- Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
- SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike
- Seroprevalence of SARS-CoV-2 in an Asymptomatic US Population
- Antibody binding to SARS-CoV-2 S glycoprotein correlates with, but does not predict neutralization
- Bacterial pulmonary superinfections are associated with unfavourable outcomes in critically ill COVID-19 patients
- The Monocyte Chemotactic Protein 1 as a Potential Indicator for SARS-CoV-2 Infected Mild COVID-19 Patients
- Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
- T cell anergy in COVID-19 reflects virus persistence and poor outcomes
- Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report
- A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody
- A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection
- Dynamic changes in serum IL-6, IL-8, and IL-10 are associated with the outcome of patients with severe COVID-19 in ICU
- KIM-1/TIM-1 is a receptor for SARS-CoV-2 in Lung and Kidney
- A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters
- Comparative evaluation of six immunoassays for the detection of antibodies against SARS-CoV-2
- Asymptomatic reinfection in two healthcare workers from India with genetically distinct SARS-CoV-2
- Laboratories biomarkers associated with COVID-19 severity and management
- The immunodominant and neutralization linear epitopes for SARS-CoV-2
- Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy
- Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients
- Longitudinal analyses reveal immunological misfiring in severe COVID-19
- Baricitinib restrains the immune dysregulation in severe COVID-19 patients
- Presence of Genetic Variants Among Young Men With Severe COVID-19
- COVID-19 severity associates with pulmonary redistribution of CD1c+ DC and inflammatory transitional and nonclassical monocytes
- Rapid evaluation of neutralizing antibodies in COVID-19 patients
- Cross-reactive antibody responses against SARS-CoV-2 and seasonal common cold coronaviruses
- Prime-boost protein subunit vaccines against SARS2 CoV-2 are highly immunogenic in mice and macaques
- Systematic examination of T cell responses to SARS-CoV-2 versus influenza virus reveals distinct inflammatory profile
- A comprehensive analysis of recovered COVID-19 patients and dynamic trend in antibodies over 3 months using ELISA and CLIA methods
- Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
- Rare SARS-CoV-2 antibody development in cancer patients
- Engineered interferon alpha effectively improves clinical outcomes of COVID-19 patients
- SARS-CoV-2 RNA viremia is associated with a sepsis-like host response and critical illness in COVID-19
- A Preliminary Study on Blood Lipid Profile in Patients with COVID-19
- Changes in lipid metabolism in patients with severe COVID-19
- Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
- SARS-CoV-2 spike protein interacts with multiple innate immune receptors
- SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2
- Pre-COVID-19 humoral immunity to common coronaviruses does not confer cross-protection against SARS-CoV-2
- Suboptimal SARS-CoV-2-specific CD8+ T-cell response associated with the prominent HLA-A*02:01 phenotype
- In plain sight: the role of alpha-1-antitrypsin in COVID-19 pathogenesis and therapeutics
- SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells
- A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
- Convalescent plasma for patients with severe COVID-19: a matched cohort study
- Decline of SARS-CoV-2 specific IgG, IgM and IgA in convalescent COVID-19 patients within 100 days after hospital discharge
- The analysis of the long-term impact of SARS-CoV-2 on the cellular immune system in individuals recovering from COVID-19 reveals a profound NKT cell impairment
- The SARS-CoV-2 Envelope and Membrane proteins modulate maturation and retention of the Spike protein, allowing optimal formation of VLPs in presence of Nucleoprotein
- IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
- Lymphopenia-induced T cell proliferation is a hallmark of severe COVID-19
- Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells
- Disease severity dictates SARS-CoV-2 specific neutralizing antibodyresponses in COVID-19
- Evidence favouring the efficacy of convalescent plasma for COVID-19 therapy
- A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses
- A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection
- Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as vaccine candidate
- A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine
- Loss expansion of SARS-CoV-2 specific immunity is a key risk factor in fatal patients with COVID-19
- Host metabolic reprogramming in response to SARS-Cov-2 infection
- SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum
- Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection
- Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
- Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) Protein Inhibits Type I and III Interferon Production by Targeting RIG-I/MDA-5 Signaling
- Infection of human lymphomononuclear cells by SARS-CoV-2
- COVID-19 and Rheumatoid Arthritis share myeloid pathogenic and resolving pathways
- Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model
- COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2
- The loss of Bcl-6 expressing T follicular helper cells and the absence of germinal centers in COVID-19
- Single cell RNA sequencing of blood antigen-presenting cells in severe Covid-19 reveals multi-process defects in antiviral immunity
- Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
- D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization
- A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip
- Circulating cytokines and lymphocyte subsets in patients who have recovered from COVID-19
- Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2
- Tissue-specific and interferon-inducible expression of non-functional ACE2 through endogenous retrovirus co-option
- SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-kB
- Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates
- Concurrent human antibody and TH1 type T-cell responses elicited by a COVID-19 RNA vaccine
- Interplay of Monocytes and T Lymphocytes in COVID-19 Severity
- SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
- Dynamics and significance of the antibody response to SARS-CoV-2 infection
- Broad phenotypic alterations and potential dysfunctions of lymphocytes in COVID-19 recovered individuals
- Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection
- SARS-CoV-2 infection induces robust, neutralizing antibody responses that are stable for at least three months
- Neutralizing Antibody Responses in COVID-19 Convalescent Sera
- COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis
- SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
- Beta-Coronaviruses use lysosomal organelles for cellular egress
- Serology in Children with Multisystem Inflammatory Syndrome (MIS-C) associated with COVID-19
- Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19
- Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19
- IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals
- Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8+ T cells
- The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
- Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)
- SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation
- Natural killer cell activation related to clinical outcome of COVID-19
- Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs
- Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19
- A shift towards an immature myeloid profile in peripheral blood of critically ill COVID-19 patients
- SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
- Baricitinib restrains the immune dysregulation in COVID-19 patients
- Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
- SARS-CoV-2 reactive T cells in uninfected individuals are likely expanded by beta-coronaviruses
- Structure of the full SARS-CoV-2 RNA genome in infected cells
- Seroconversion of a city: Longitudinal monitoring of SARS-CoV seroprevalence in New York City
- SARS-CoV-2 serological testing using electrochemiluminescence reveals a rapid onset of seroconversion in severe COVID-19 patients
- Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes
- In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age
- Proteomic blood profiling in mild, severe and critical COVID-19 patients
- A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection
- Elevated Nucleoprotein-Induced Interferon-γ Release in COVID-19 Patients Detected in a SARS-CoV-2 Enzyme-Linked Immunosorbent Spot Assay
- Neuroinvasive potential of SARS-CoV-2 revealed in a human brain organoid model
- Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune Response without Seroconversion
- Tocilizumab and steroid treatment in patients with COVID-19 pneumonia
- In silico immune infiltration profiling reveals the role of naïve B cells in lung tissues of COVID-19 patients
- Spectrum of innate and adaptive immune response to SARS CoV 2 infection across asymptomatic, mild and severe cases; a longitudinal cohort study
- Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system
- Two distinct immunopathological profiles in lungs of lethal COVID-19
- SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids
- Longitudinal immunological analyses reveal inflammatory misfiring in severe COVID-19 patients
- Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients
- Antiviral Drug Screen of Kinase inhibitors Identifies Cellular Signaling Pathways Critical for SARS-CoV-2 Replication
- Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19
- Early temporal dynamics of cellular responses to SARS-CoV-2
- Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection
- NK cell receptor NKG2C deletion and HLA-E variants are risk factors for severe COVID-19
- Living repository of millions of T and B cell receptor sequences from patients with COVID-19
- A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
- SARS-CoV-2 T-cell epitopes define heterologous and COVID-19-induced T-cell recognition
- A longitudinal study of immune cells in severe COVID-19 patients
- Microscopy-based assay for semi-quantitative detection of SARS-CoV2 specific antibodies in human sera
- Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
- A single dose of an adenovirus-vectored vaccine provides complete protection of the upper and lower respiratory tracts against SARS-CoV-2 challenge
- SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients
- Drug repurposing screens reveal FDA approved drugs active against SARS-CoV-2
- Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
- Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells
- Age-dependent progression of SARS-CoV-2 infection in Syrian hamsters
- Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2
- Highly sensitive and specific multiplex antibody assays to quantify immunoglobulins M, A and G against SARS-CoV-2 antigens
- Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
- Cross-reactivity of neutralizing antibody and its correlation with circulating T follicular cells in recovered COVID-19 individuals
- Engineering mesenchymal stem cells with neutralizing and anti- inflammation dual-capability against SARS-CoV-2 infection
- SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models
- IgA dominates the early neutralizing antibody response to SARS-CoV-2
- Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate
- SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology
- SARS-CoV-2-specific T cells exhibit unique features characterized by robust helper function, lack of terminal differentiation, and high proliferative potential
- Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients
- Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19
- Remdesivir but not famotidine inhibits SARS-CoV-2 replication in human pluripotent stem cell-derived intestinal organoids
- Immune Response Profile of SARS-CoV-2 Associated ARDS Patients During Extracorporeal Membrane Oxygenation
- Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
- Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
- A consensus Covid-19 immune signature combines immune-protection with discrete sepsis-like traits associated with poor prognosis
- SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness
- Profound CD8 T cell responses towards the SARS-CoV-2 ORF1ab in COVID-19 patients
- Acute SARS-CoV-2 infection impairs dendritic cell and T cell responses
- SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface
- Therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022
- SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus
- Gut mycobiota alterations in patients with COVID-19 and H1N1 and associations with immune and gastrointestinal symptoms
- Targeted Immunosuppression Distinguishes COVID-19 from Influenza in Moderate and Severe Disease
- An open resource for T cell phenotype changes in COVID-19 identifies IL-10-producing regulatory T cells as characteristic of severe cases
- Activation of Peroxiredoxin 1 by Fluvastatin Effectively Protects from Inflammation and SARS-CoV-2
- Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects
- Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge
- Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity
- Expansion of SARS-CoV-2-specific Antibody-secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients
- Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors
- Suppressive myeloid cells are a hallmark of severe COVID-19
- SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
- Metatranscriptomic Characterization of COVID-19 Identified A Host Transcriptional Classifier Associated With Immune Signaling
- Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals
- Chemokine Receptor Inhibitor vMIP-II Promoting Lymphocytes in COVID-19 Patients and Its Related Mechanism In Vitro
- Development and validation of IMMUNO-COVTM: a high-throughput clinical assay for detecting antibodies that neutralise SARS-CoV-2
- Single-Cell Analysis Reveals Macrophage-Driven T Cell Dysfunction in Severe COVID-19 Patients
- Sars-Cov-2 Spike 1 protein control Natural killer cells activation via HLA-E/NKG2A pathway
- Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis dependent axis
- Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19
- Generation of human bronchial organoids for SARS-CoV-2 research
- A systems approach to inflammation identifies therapeutic targets in SARSCoV-2 infection
- Impaired T cell functions along with elevated activated Tregs at the early stage of asymptomatic SARS-CoV-2 infection
- Identification of immune complement function as a determinant of adverse SARS-CoV-2 infection outcome
- Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2
- SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors
- Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
- The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I
- Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates
- Angiotensin-converting enzyme 2, a SARS-CoV-2 receptor, is upregulated by interleukin-6 via STAT3 signaling in rheumatoid synovium
- Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
- Integrated sample inactivation, amplification, and Cas13-based detection of SARS-CoV-2
- Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir
- Single-cell RNA-seq and V(D)J profiling of immune cells in COVID-19 patients
- Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease
- Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells
- SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencing
- Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis
- The SARS-CoV-2 spike protein primes inflammasome-mediated interleukin-1- beta secretion in COVID-19 patient-derived macrophages
- Tropism, replication competence, and innate responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures
- Symptomatic SARS-CoV-2 infections display specific IgG Fc structures
- A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
- The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators
- Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals
- The SARS-CoV-2 T-cell immunity is directed against the spike, membrane, and nucleocapsid protein and associated with COVID 19 severity
- Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
- Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells
- SARS-CoV-2 infection protects against rechallenge in rhesus macaques
- Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses
- Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
- Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
- DNA vaccine protection against SARS-CoV-2 in rhesus macaques
- Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures
- SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects
- Convalescent plasma treatment of severe COVID-19: A matched control study
- Transcriptional profiling of immune and inflammatory responses in the context of SARS-CoV-2 fungal superinfection in a human airway epithelial model
- Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
- In Search of Preventative Strategies: Novel Anti- Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues
- Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases
- Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19
- The anticoagulant nafamostat potently inhibits SARS-CoV-2 infection in vitro： an existing drug with multiple possible therapeutic effects
- Robust ACE2 protein expression localises to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
- Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
- Serum protein profiling reveals a landscape of inflammation and immune signalling in early-stage COVID-19 infection
- Novel ACE2-Independent Carbohydrate-Binding of SARS-CoV-2 Spike Protein to Host Lectins and Lung Microbiota
- Longitudinal Profiling of Cytokines and Chemokines in COVID-19 Reveals Inhibitory Mediators IL-1Ra and IL-10 Are Associated with Disease Severity While Elevated RANTES Is an Early Predictor of Mild Disease
- Infection of bat and human intestinal organoids by SARS-CoV-2
- Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19
- Reappearance of Effector T Cells Predicts Successful Recovery from COVID-19
- A Translatable Subunit Nanovaccine for COVID-19
- Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
- Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19
- Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans
- Distinct conformational states of SARS-CoV-2 spike protein
- Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
- Potent neutralization of SARS-CoV-2 in vitro and in an animal model by a human monoclonal antibody
- ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques
- A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities
- Rapid response flow cytometric assay for the detection of antibody 2 responses to SARS-CoV-2
- A rapid, point of care red blood cell agglutination assay for detecting antibodies against SARS-CoV-2
- Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection
- SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant
- Suramin inhibits SARS-CoV-2 infection in cell culture by interfering with early steps of the replication cycle
- Evidence of a significant secretory-IgA-dominant SARS-CoV-2 immune response in human milk following recovery from COVID-19
- Neutrophil calprotectin identifies severe pulmonary disease in COVID-19
- SARS-CoV-2 Infection of the Placenta
- Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site
- Mass spectrometry analysis of newly emerging coronavirus HCoV-19 spike S protein and human ACE2 reveals camouflaging glycans and unique post-translational modifications
- A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells
- Replication of SARS-CoV-2 in human respiratory epithelium
- Treatment of Severe COVID-19 with human Umbilical Cord Mesenchymal Stem Cells
- Characteristics of lymphocyte subsets and their predicting values for the severity of COVID-19 patients
- B cell clonal expansion and convergent antibody responses to SARS-CoV-2
- Identification of immune checkpoints in COVID-19
- Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
- Comprehensive characterization of N- and O- glycosylation of SARS- CoV-2 human receptor angiotensin converting enzyme 2
- Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients
- Shared Antigen-specific CD8 T cell Responses Against the SARS-COV-2 Spike Protein in HLA-A*02:01 COVID-19 Participants
- Immune alterations during SARS-CoV-2-related acute respiratory distress syndrome
- Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform
- Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identify molecular targets for therapeutic intervention
- Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19
- Early viral clearance and antibody kinetics of COVID-19 among asymptomatic carriers
- A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures
- Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19
- Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease: A retrospective study
- Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non- human primates
- A non-competing pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
- Host-viral infection maps reveal signatures of severe COVID-19 patients
- An age dependent pharyngeal microbiota signature associated with SARS-CoV-2 infection
- Rapid adaption of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy
- Viral Invasion and Type I Interferon Response Characterize the Immunophenotypes During Covid-19 Infection
- Use of siltuximab in patients with COVID-19 pneumonia requiring ventilatory support
- SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems
- Increased circulating microparticles and inflammatory factors aggravate coronavirus disease 2019 (COVID19)
- Lectin-like intestinal defensin inhibits 2019-nCoV spike binding to ACE2
- Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2
- Virological assessment of hospitalised patients with COVID-2019
- Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice
- Distinct Inductions of and Responses to Type I and Type III Interferons Promote Infections in Two SARS-CoV-2 Isolate
- A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques
- Successful manufacturing of clinical grade SARS-CoV-2 specific T cells for adoptive T cell therapy
- Critically ill SARS-CoV-2 patients display lupus-like hallmarks of extrafollicular B cell activation
- Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation
- Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies
- Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells
- Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model
- Heightened innate immune responses in the respiratory tract of COVID-19 patients
- A possible role of immunopathogenesis in COVID-19 progression
- Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin
- All-in-One Dual CRISPR-Cas12a (AIOD-CRISPR) Assay: A Case for Rapid, Ultrasensitive and Visual Detection of Novel Coronavirus SARS-CoV-2 and HIV virus
- Thymosin alpha-1 Protected T Cells from Excessive Activation in Severe COVID-19
- Detection of SARS-COV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals
- Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids
- Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
- TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
- A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
- Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
- Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients
- SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues
- Shotgun proteomics of SARS-CoV-2 infected cells and its application to the optimisation of whole viral particle antigen production for vaccines
- A single-cell atlas of the peripheral immune response to severe Covid-19
- Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection, Replication and Spread in Primary Human Intestinal Epithelial Cells
- SARS-CoV-2 Productively Infects Human Gut Enterocytes
- TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes
- Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
- Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
- Gut microbiota may underlie the predisposition of healthy individuals to COVID-19
- SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
- Rapid development of an inactivated vaccine for SARS-CoV-2
- Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases
- COVID-19 diagnosis and study of serum SARS-CoV-2 specific IgA, IgM and IgG by a quantitative and sensitive immunoassay
- Treating Influenza and SARS-CoV-2 via mRNA-encoded Cas13a
- Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients
- A SARS-CoV-2 surrogate virus neutralization test (sVNT) based on antibody-mediated blockade of ACE2-spike (RBD) protein-protein interaction
- Marked T cell activation, senescence, exhaustion and skewing towards Th17 in patients with Covid-19 pneumonia
- Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs
- Efficacy and safety of lopinavir/ritonavir or arbidol in adult patients with mild/moderate COVID-19: an exploratory randomized controlled trial
- Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
- Survival Factors and Metabolic Pathogenesis in Elderly Patients (≥65) with COVID-19 : A multi-center study of 223 Cases
- Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19
- STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters
- The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia
- Increased expression of CD8 marker on T-cells in COVID-19 patients
- Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
- Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series
- Acute eosinophilic pneumonia associated with elevated NKT cell response in COVID-19 patients
- Neutrophil extracellular traps (NETs) as markers of disease severity in COVID-19
- Persistent SARS-CoV-2 presence is companied with defects in adaptive immune system in non-severe COVID-19 patients
- CRISPR–Cas12-based detection of SARS-CoV-2
- Humanized Single Domain Antibodies Neutralize SARS-CoV-2 by Targeting 2 Spike Receptor Binding Domain
- Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study
- Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy
- Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
- Multiscale 3-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy
- Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome
- Identification of 22 N-glycosites on Spike glycoprotein of SARS-CoV-2 and accessible surface glycopeptide motifs: implications on vaccination and antibody therapeutics
- The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-CoV-2) replication and attenuates inflammation in human cells
- Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2- mediated complement over-activation
- Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza
- Imbalanced host response to SARS-CoV-2 drives development of COVID-19
- A serological assay to detect SARS-CoV-2 seroconversion in humans
- Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases
- Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia
- Analytical Validation of a COVID-19 qRT-PCR Detection Assay Using a 384-well Format and Three Extraction Methods
- Potent human neutralizing antibodies elicited by SARS-CoV-2 infection
- SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
- A dynamic immune response shapes COVID-19 progression
- Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene 3 expression in the airway epithelium
- Effectiveness of convalescent plasma therapy in severe COVID-19 patients
- Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis
- Complex immune dysregulation in COVID-19 patients with severe respiratory failure
- The phenotypic changes of γδ T cells in COVID-19 patients
- Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS- CoV-2 by Remdesivir
- Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production
- Reinfection could not occur in SARS-CoV-2 infected rhesus macaques
- Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro
- Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study
- SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
- Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice
- Immunoglobulin fragment F(ab’)2 against RBD potently neutralizes SARS-CoV-2 in vitro
- An Infectious cDNA Clone of SARS-CoV-2
- Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection
- Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2
- Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)
- Rapid development of a synthetic DNA vaccine for COVID-19
- An Effective CTL Peptide Vaccine for Ebola Zaire Based on Survivors' CD8+ Targeting of a Particular Nucleocapsid Protein Epitope with Potential Implications for COVID-19 Vaccine Design
- Analysis of adaptive immune cell populations and phenotypes in the patients infected by SARS-CoV-2
- The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice
- Structural basis of receptor recognition by SARS-CoV-2
- Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients
- Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including the newly emerged coronavirus SARS-CoV-2
- Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells
- The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes
- Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
- Structure, function and antigenicity of the SARS-CoV-2 Spike Protein
- A human monoclonal antibody blocking SARS-CoV-2 infection
- Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV
- SARS-CoV-2 may persist in digestive tract longer than respiratory tract
- Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
- ACE2 expression by colonic epithelial cells is associate with viral infection, immunity and energy metabolism
- Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus
- Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19
- Dysregulation of immune response in patients with COVID-19 in Wuhan, China
- The potential role of IL-6 in monitoring severe case of coronavirus disease 2019
- Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
- Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study
- SARS-CoV-2 is sensitive to type 1 interferon pretreatment
- SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor
- Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing
- Alveolar macrophage activation and cytokine storm in the pathogenesis of severe COVID-19
- Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
- Publications from Oxford Immunology Network Researchers