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In mammals, most new mutations occur in males. But a study of the evolution of a human X to Y chromosomal translocation has revealed a sex bias much lower than previous estimates. Patterns of substitution suggest that differential methylation between male and female germ lines is a key determinant of the mutation rate.


Journal article


Curr Biol

Publication Date





R834 - R835


Animals, CpG Islands, DNA Methylation, Evolution, Molecular, Female, Humans, Male, Sexual Maturation, Translocation, Genetic, X Chromosome, Y Chromosome