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The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Original publication

DOI

10.1038/ng.218

Type

Journal article

Journal

Nat Genet

Publication Date

10/2008

Volume

40

Pages

1156 - 1159

Keywords

Arthritis, Rheumatoid, Case-Control Studies, Chromosome Mapping, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 22, Genetic Linkage, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide