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Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressing this challenge, allowing the detection and quantification of conserved architectural properties between proteins, including those with low or no detectable sequence homology. With a focus on viral protein structure, we highlight how a number of investigations have utilized this powerful method to infer common functionality and ancestry.

Original publication

DOI

10.1093/ve/veaa003

Type

Journal article

Journal

Virus Evol

Publication Date

01/2020

Volume

6

Keywords

evolution, function, protein, structure, virus