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CNS involvement is a common feature of metastatic melanoma. Despite this, there is little evidence upon which clinicians can base decisions about treatment. The short prognosis and significant symptoms usually associated with melanoma brain metastases have excluded these patients from clinical trials. In Europe the standard treatment involves whole brain radiotherapy, although selected centers offer other modalities, including surgery, radiosurgery, and chemotherapy.


Journal article


Semin Oncol

Publication Date





513 - 517


Antineoplastic Agents, Brain Neoplasms, Combined Modality Therapy, Cranial Irradiation, Humans, Melanoma, Radiosurgery, Skin Neoplasms