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The present invention relates t o BMPs (bone morphogenetic proteins) which regulate metabolic homeostasis of iron, fats and carbohydrates. In particular, the present invention relates t o methods for treating a disease of iron metabolism or a disease comprising abnormally high or low hepcidin levels or abnormally high or abnormally low iron levels using a BMP agonist or antagonist. The present invention further relates t o methods for treating a disease of fat or carbohydrate metabolism using a BM Pagonist or antagonist. The present invention further relates t o methods for treating a disease of iron metabolism or treating a disease of fat or carbohydrate metabolism by inhibition of the interaction between BMPs and erythroferrone (ERFE) / FAM 132b.

Type

Patent

Publication Date

12/12/2019

Addresses

Kirsty McHugh, University of Oxford, Jenner Institute, ORCB Old Road, Oxford, NA, OX37DQ, United Kingdom

Keywords

BMP, erythroferrone, iron, thalassemia, treatment, antibody