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Fourteen children with no detectable bactericidal antibody response to a first dose of meningococcal C conjugate vaccine at 4 years of age were given a booster dose of the same vaccine 2 years later. A rapid 1000-fold rise in postimmunization bactericidal antibody titers, a measured either 7 or 14 days later, suggested previous immunologic priming.


Journal article


Pediatr Infect Dis J

Publication Date





659 - 661


Antibodies, Bacterial, Antibody Formation, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Immunization Schedule, Immunization, Secondary, Immunologic Memory, Male, Meningococcal Infections, Meningococcal Vaccines, Neisseria meningitidis, Probability, Prospective Studies, Sampling Studies, Sensitivity and Specificity, Time Factors