Infusion of regulatory T cells is a promising therapeutic strategy in organ transplantation to modulate the immune system, prevent rejection, minimize the need for pharmaceutical immunosuppression, and improve long-term transplant outcomes. Here we describe a GMP-compliant method we have used for the manufacture of ex vivo expanded autologous regulatory T cells for use in clinical trials.
Chapter
2023
2559
205 - 227
Immunosuppression minimization, Regulatory T cells, Tolerance, Transplantation, Treg, Graft Rejection, Immune Tolerance, Immunosuppression Therapy, Organ Transplantation, Pharmaceutical Preparations, T-Lymphocytes, Regulatory