Zhang H., Kalla R., Chen J., Zhao J., Zhou X., Adams A., Noble A., Ventham NT., Wellens J., Ho G-T., Dunlop MG., Nowak JK., Ding Y., Liu Z., Satsangi J., Theodoratou E., Li X.

This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking behaviors, smoking-related DNA methylation and the risks of Crohn's disease (CD) and ulcerative colitis (UC). We then perform both genome-wide methylation analysis and co-localization analysis to validate the observed associations. Compared to never smoking, current and previous smoking habits are associated with increased CD (P = 7.09 × 10-10) and UC (P

Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease.

Zhang H., Kalla R., Chen J., Zhao J., Zhou X., Adams A., Noble A., Ventham NT., Wellens J., Ho G-T., Dunlop MG., Nowak JK., Ding Y., Liu Z., Satsangi J., Theodoratou E., Li X.

DOI

Type

Journal

Publication Date

Volume