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Macrophage molecules involved in adhesion, signalling, secretion and interactions with pathogens and T-helper lymphocytes have been cloned and defined using monoclonal antibodies and genetic disruption. Studies of the regulation of macrophage differentiation and activation by cytokines have yielded insights into the heterogeneity of their functions in natural and acquired immunity, including immunity to infections by mycobacteria and HIV.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

02/1995

Volume

7

Pages

24 - 33

Keywords

Animals, Humans, Macrophages, Molecular Biology, Receptors, Cell Surface