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Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771.

Chen TS., Arison BH., Wicker LS., Inamine ES., Monaghan RL.

The immunosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

Original publication

DOI

10.7164/antibiotics.45.118

Type

Journal

J Antibiot (Tokyo)

Publication Date

01/1992

Volume

45

Pages

118 - 123

Keywords

Actinomycetales, Animals, Cells, Cultured, Chromatography, High Pressure Liquid, Fermentation, Immunosuppressive Agents, Magnetic Resonance Spectroscopy, Mass Spectrometry, Methylene Chloride, Mice, Molecular Conformation, Molecular Structure, Piperidines, Spectrometry, Mass, Fast Atom Bombardment, T-Lymphocytes, Tacrolimus