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HIV type 2 (HIV-2), a closely related retrovirus discovered a few years after HIV type 1, causes AIDS in only a minority of infected individuals. Determining why HIV-2 causes asymptomatic infection in most patients could further our understanding of HIV immunopathogenesis. Studies to date have suggested that both enhanced immune responses and lower viral replication could play a role. We summarize the important findings to date and highlight areas that warrant further exploration.

Original publication

DOI

10.1016/j.tim.2008.09.003

Type

Journal article

Journal

Trends Microbiol

Publication Date

12/2008

Volume

16

Pages

588 - 595

Keywords

Animals, HIV Antibodies, HIV Infections, HIV-2, Humans, Prevalence