Figure 5 from Coevolution of Atypical <i>BRAF</i> and <i>KRAS</i> Mutations in Colorectal Tumorigenesis
Woolley CE., Domingo E., Fernandez-Tajes J., Pennel KAF., Roxburgh P., Edwards J., Richman SD., Maughan TS., Kerr DJ., Soriano I., Tomlinson IPM.
<p>mRNA expression of the EGFR ligands <i>AREG</i> and <i>EREG</i>. <b>A,</b> Expression of <i>AREG</i> and <i>EREG</i> is significantly increased in the distal colorectum vs. proximal colon across the INTERMPHEN (<i>n</i> = 119 proximal and <i>n</i> = 236 distal colorectum) and TCGA COADREAD (<i>n</i> = 18 proximal and <i>n</i> = 19 distal/rectal). Log<sub>2</sub>FC and significance values obtained via DESeq2 analysis (see Materials and Methods). <b>B,</b> Expression of <i>EREG</i> is significantly increased in class 3 <i>BRAF</i>-mutant colorectal cancers vs. class 1 in the absence of a concomitant Ras mutation (<i>P</i>.adj < 0.005), which may reflect the distal colorectum bias of class 3 mutations. (Created with <a href="http://BioRender.com" target="_blank">BioRender.com</a>.)</p>