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The Plasma concentrations of a lipophilic furan dicarboxylic acid (3- carboxy-4-methyl-5-propyl-2-fluranpropanoic acid; 5-propyl FPA), which is highly bound to albumin and not removed by haemodialysis, have been measured in patients with renal impairment who were not dialysis dependent or who were treated by either haemodialysis or peritoneal dialysis. Neurological abnormalities were assessed as absent, moderate, or severe. A relationship was observed between the increasing severity of abnormalities attributable to the uraemic state and the higher plasma concentrations of 5-propyl FPA. There are theoretical grounds for believing that 5-propyl FPA contributes to these neurological abnormalities because of its structure and also because it inhibits the transport of organic acids in the kidney and could do likewise at the blood-brain barrier.

Original publication

DOI

10.1159/000189035

Type

Journal article

Journal

Nephron

Publication Date

1996

Volume

73

Pages

169 - 173

Keywords

Furans, Humans, Kidney Failure, Chronic, Nervous System Diseases, Peritoneal Dialysis, Continuous Ambulatory, Propionates, Renal Dialysis