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Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as the existence of the benign steady state, or predicted incorrectly the size of the inter-tissue gap. Here we show that taking proper account of quiescence ameliorates these drawbacks as well as revealing novel behaviour. The simplicity of the model allows us to fully identify the key parameters controlling different aspects of behaviour.

Original publication

DOI

10.1016/j.jtbi.2008.08.002

Type

Journal article

Journal

J Theor Biol

Publication Date

07/11/2008

Volume

255

Pages

106 - 112

Keywords

Animals, Cell Death, Computer Simulation, Disease Progression, Humans, Hydrogen-Ion Concentration, Models, Biological, Models, Statistical, Necrosis, Neoplasm Invasiveness, Neoplasms, Neovascularization, Pathologic