Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

In this short review we examine the recently identified immunoglobulin-like transcript (ILT) family of receptors (also known as LIR and MIR). ILT are expressed by many leukocyte subsets, especially monocytic cells. Expression levels of certain ILT molecules allow definition of blood monocyte and dendritic cell (DC) subsets. Two receptors, ILT2 and ILT4, recognise a broad range of MHC class I molecules and transduce an inhibitory signal. Such recognition may give many cell lineages the potential to recognise and respond to MHC class I down-regulation.

Original publication

DOI

10.1016/S0171-2985(00)80050-9

Type

Journal article

Journal

Immunobiology

Publication Date

05/2000

Volume

202

Pages

34 - 41

Keywords

Animals, Humans, Leukocytes, Receptors, Immunologic, Signal Transduction