Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4(+)- or CD8(+)-restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8(+) T cells can play a protective role against tuberculosis.

Original publication




Journal article


Infect Immun

Publication Date





1623 - 1626


Acyltransferases, Amino Acid Sequence, Animals, Antigen Presentation, Antigens, Bacterial, BCG Vaccine, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Dendritic Cells, Epitopes, Female, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Tuberculosis, Vaccination