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Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4(+)- or CD8(+)-restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8(+) T cells can play a protective role against tuberculosis.

Original publication

DOI

10.1128/iai.70.3.1623-1626.2002

Type

Journal article

Journal

Infect Immun

Publication Date

03/2002

Volume

70

Pages

1623 - 1626

Keywords

Acyltransferases, Amino Acid Sequence, Animals, Antigen Presentation, Antigens, Bacterial, BCG Vaccine, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Dendritic Cells, Epitopes, Female, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Tuberculosis, Vaccination