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Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Heterologous prime-boost immunisation strategies induce higher levels of both CD4+ and CD8+ T cells than homologous boosting with the same vector. Recombinant pox-viruses are particularly good at boosting previously primed T cell responses. Using BCG as the priming immunisation in such a heterologous prime-boost strategy is a practical solution, which allows the beneficial effects of BCG in children to be maintained.

Original publication

DOI

10.1016/j.micinf.2005.03.009

Type

Journal article

Journal

Microbes Infect

Publication Date

05/2005

Volume

7

Pages

962 - 967

Keywords

Humans, Immunization Schedule, Immunization, Secondary, Tuberculosis Vaccines