Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus. In this study, we show that LEF1 and TCF7 (TCF-1) are not only expressed in thymocytes, but also in mature T cells. Our data demonstrate that Ag encounter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of LEF1 and TCF7 (TCF-1) expression in human naive CD8 T cells. We further show that resting T cells preferentially express inhibitory LEF1 and TCF7 (TCF-1) isoforms and that T cell activation changes the isoform balance in favor of stimulatory TCF7 (TCF-1) isoforms. Altogether, our study suggests that proteins involved in the WNT signaling pathway not only regulate T cell development, but also peripheral T cell differentiation.

Original publication

DOI

10.4049/jimmunol.176.3.1439

Type

Journal article

Journal

J Immunol

Publication Date

01/02/2006

Volume

176

Pages

1439 - 1446

Keywords

Antigens, CD8-Positive T-Lymphocytes, Cell Differentiation, Cells, Cultured, Down-Regulation, Gene Expression Profiling, Humans, Interleukin-15, Lymphoid Enhancer-Binding Factor 1, Protein Isoforms, Receptors, Antigen, T-Cell, Resting Phase, Cell Cycle, Signal Transduction, T Cell Transcription Factor 1, T-Lymphocyte Subsets, Wnt Proteins