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Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB1*15 haplotypes stratified by sex of transmitting parent. A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS.

Original publication




Journal article


Hum Genet

Publication Date





661 - 663


Child, Cohort Studies, Family, Female, Genetic Predisposition to Disease, Genotype, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Inheritance Patterns, Male, Multiple Sclerosis, Parents