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Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.

Original publication




Journal article


Nat Biotechnol

Publication Date





1280 - 1284


Amino Acid Sequence, Animals, Epitopes, Female, Humans, Malaria Vaccines, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Plasmodium berghei, Plasmodium falciparum, T-Lymphocytes, Cytotoxic