Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Original publication

DOI

10.1128/jvi.76.20.10507-10511.2002

Type

Journal article

Journal

J Virol

Publication Date

10/2002

Volume

76

Pages

10507 - 10511

Keywords

Animals, CD4-Positive T-Lymphocytes, Cell Division, Epitopes, T-Lymphocyte, Gene Products, gag, Histocompatibility Antigens Class I, Humans, Immunodominant Epitopes, Macaca mulatta, Simian Immunodeficiency Virus, T-Lymphocytes, Cytotoxic, Vaccination