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We were seeking for a mutual link between the -174G>C IL6 promoter polymorphism, history of the past acute respiratory infections and the long-term post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence. Two hundred thirty seven post-CABG patients have been followed up for a median period of 36 months. We found that past acute infections, influenza-like illness and lack of vaccination against influenza confer a significant risk of the post-CABG MACE incidence in the -174G allele carrying patients.

Original publication




Journal article


Int J Cardiol

Publication Date





421 - 422


Acute Disease, Aged, Cohort Studies, Comorbidity, Coronary Artery Bypass, Coronary Disease, Female, Gene Expression Regulation, Humans, Influenza, Human, Interleukin-6, Male, Middle Aged, Polymorphism, Genetic, Postoperative Complications, Prognosis, Respiratory Tract Infections, Risk Assessment, Treatment Outcome