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Anticoagulant activities against the extrinsic and intrinsic coagulation pathways were identified in salivary gland extracts (SGE) prepared from four tabanids (Hybomitra muehlfeldi, Tabanus autumnalis, Haematopota pluvialis, Heptatoma pellucens). All extracts prolonged human plasma clotting time in a dose-dependent manner and inhibited thrombin activity in the chromogenic substrate assay. Horsefly SGE did not inhibit factor Xa. Partial purification of SGE proteins using reversed-phase high-performance liquid chromatography revealed species-specific differences in the elution profiles and range of fractions with anticoagulant activities.

Original publication

DOI

10.1159/000048076

Type

Journal article

Journal

Haemostasis

Publication Date

05/2001

Volume

31

Pages

294 - 305

Keywords

Animals, Anticoagulants, Arthropod Venoms, Blood Coagulation, Blood Coagulation Tests, Cell Extracts, Chromatography, High Pressure Liquid, Diptera, Factor Xa, Humans, Salivary Glands, Species Specificity, Thrombin