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Like T cell activation, B cell activation is driven by aggregation of B cell receptors (BCRs) into microclusters. New work suggests that the early dynamics of BCR mobility and microcluster formation "translate" BCR affinity for antigen into B cell responsiveness.

Original publication

DOI

10.1084/jem.20100780

Type

Journal article

Journal

J Exp Med

Publication Date

10/05/2010

Volume

207

Pages

907 - 909

Keywords

Actins, Animals, B-Lymphocytes, Cytoskeletal Proteins, Genetic Engineering, Immunological Synapses, Lymphocyte Activation, Mice, Models, Immunological, Receptors, Antigen, B-Cell, Signal Transduction, T-Lymphocytes