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Interleukin 2 (IL-2) was one of the first cytokines to be discovered. However, the complex role of IL-2 and its receptor in the regulation of immune responses is only now emerging. This review explores the various signals triggered by IL-2 and discusses their translation into biological function. A model is outlined that accommodates the seemingly contradictory functions of IL-2, and explains how one cytokine can be an essential T-cell growth and differentiation factor and yet also be indispensable to maintain peripheral tolerance.

Original publication

DOI

10.1038/sj.embor.7401099

Type

Journal article

Journal

EMBO Rep

Publication Date

12/2007

Volume

8

Pages

1142 - 1148

Keywords

Animals, Humans, Immunity, Active, Immunization, Interleukin-2, Models, Biological, T-Lymphocytes