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The majority of solid tumours arise in epithelia and therefore much research effort has gone into investigating the growth, renewal and regulation of these tissues. Here we review different mathematical and computational approaches that have been used to model epithelia. We compare different models and describe future challenges that need to be overcome in order to fully exploit new data which present, for the first time, the real possibility for detailed model validation and comparison.

Original publication

DOI

10.3934/mbe.2015.12.1321

Type

Journal article

Journal

Math Biosci Eng

Publication Date

12/2015

Volume

12

Pages

1321 - 1340

Keywords

Animals, Carcinogenesis, Epithelium, Homeostasis, Humans, Mathematical Concepts, Models, Biological, Neoplasms, Glandular and Epithelial