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Glycan analysis of virion-derived glycoproteins is challenging due to the difficulties in glycoprotein isolation and low sample abundance. Here, we describe how ion mobility mass spectrometry can be used to obtain spectra from virion samples. We also describe how negative ion fragmentation of glycans can be used to probe structural features of virion glycans.

Original publication

DOI

10.1007/978-1-4939-2874-3_7

Type

Journal article

Journal

Methods Mol Biol

Publication Date

2015

Volume

1331

Pages

93 - 121

Keywords

Animals, Cell Line, Cricetinae, Glycoproteins, Glycosylation, Ions, Polysaccharides, Spectrometry, Mass, Electrospray Ionization, Viral Proteins