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Anemia is common among people living in low- and middle-income countries, and alleviation of the global burden of anemia is an essential global health target over the next decade. Estimates have attributed about half the cases of anemia worldwide to iron deficiency; a range of other causes probably make a similar overall contribution. Individuals living in low-income settings experience a simultaneous high burden of infection with inflammation and iron deficiency. At least in children, iron supplementation exacerbates the risk of infection in both malaria-endemic and nonendemic low-income countries, whereas iron deficiency is protective against clinical and severe malaria.

Original publication

DOI

10.1016/j.hoc.2015.11.003

Type

Journal article

Journal

Hematol Oncol Clin North Am

Publication Date

04/2016

Volume

30

Pages

309 - 325

Keywords

Anemia, Children, Hepcidin, Infection, Iron, Malaria, Public health, Anemia, Iron-Deficiency, Female, Global Health, Humans, Male, Pregnancy, Prevalence