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Although best known for inducing inflammasome formation and pyroptosis in myeloid cells, increasing evidence highlights additional roles for Nod-like receptors (NLR) in nonhematopoietic cells. Two recent studies demonstrate that NLRX1 functions as an intrinsic tumor suppressor in intestinal epithelial cells (IEC), by regulating their responses to proliferative signals following intestinal injury.

Original publication

DOI

10.1016/j.it.2016.07.004

Type

Journal article

Journal

Trends Immunol

Publication Date

09/2016

Volume

37

Pages

569 - 570

Keywords

Animals, Cell Proliferation, Colonic Neoplasms, Gastritis, Homeostasis, Humans, Immunity, Innate, Intestinal Mucosa, Meningitis, Mice, Mice, Knockout, Mitochondrial Proteins, Pneumonia, Signal Transduction, Tumor Suppressor Proteins