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Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.

Original publication

DOI

10.1038/329599a0

Type

Journal article

Journal

Nature

Publication Date

15/10/1987

Volume

329

Pages

599 - 604

Keywords

Alleles, Amino Acid Sequence, Base Sequence, Chromosomes, Human, Pair 6, Diabetes Mellitus, Type 1, Disease Susceptibility, Genetic Linkage, HLA-D Antigens, HLA-DQ Antigens, HLA-DR Antigens, Haploidy, Histocompatibility Antigens Class II, Humans, Immunity, Innate, Islets of Langerhans, Molecular Sequence Data, Oligonucleotides, Polymorphism, Genetic