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Recently, the major advances in understanding the genetics of type 1 diabetes have come using the positional cloning approach, both in mouse and human. Construction of congenic mouse strains and, in human, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.

Original publication

DOI

10.1055/s-2007-979795

Type

Conference paper

Publication Date

06/1996

Volume

28

Pages

289 - 293

Keywords

Animals, Chromosome Mapping, Diabetes Mellitus, Type 1, Genetic Linkage, Haplotypes, Humans, Mice, Mice, Inbred NOD