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In this issue of Immunity, Funabiki et al. (2014) have identified in mice a mutation of the IFIH1 gene, encoding the viral receptor MDA5 that causes constitutive IFN production and fatal autoimmune disease. The authors show that the autoimmune disease-associated variant of human MDA5 is permanently switched on.

Original publication

DOI

10.1016/j.immuni.2014.01.009

Type

Journal article

Journal

Immunity

Publication Date

20/02/2014

Volume

40

Pages

167 - 169

Keywords

Animals, Autoimmune Diseases, DEAD-box RNA Helicases