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As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to individual immune-mediated diseases, as well as evidence that some genes are associated with more than one disease. In this study, we tested 17 single nucleotide polymorphisms (SNP) from 16 gene regions that have been reported in several autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), ankylosing spondylitis (AS) and Crohn’s disease (CD) to determine whether the variants are also associated with type 1 diabetes (T1D). In up to 8010 cases and 9733 controls we found some evidence for an association with T1D in the regions containing genes: 2q32/STAT4, 17q21/STAT3, 5p15/ERAP1 (ARTS1), 6q23/TNFAIP3 and 12q13/KIF5A/PIP4K2C with allelic P-values ranging from 3.70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus.

Original publication

DOI

10.1038/gene.2008.99

Type

Journal article

Journal

Genes Immun

Publication Date

03/2009

Volume

10

Pages

188 - 191

Keywords

Autoimmune Diseases, Chromosomes, Human, Pair 6, DNA-Binding Proteins, Diabetes Mellitus, Type 1, Female, Genetic Predisposition to Disease, Humans, Intracellular Signaling Peptides and Proteins, Male, Nuclear Proteins, Polymorphism, Single Nucleotide, Quantitative Trait Loci